SH2D4A Polyclonal Antibody

Catalogue Numbers: BS61270-50, BS61270-100

Sizes: 50µl, 100µl

Alternative Name: SH2 domain-containing protein 4A; Protein SH(2)A; Protein phosphatase 1 regulatory subunit 38; SH2D4A; PPP1R38; SH2A

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9H788

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: SH2D4A (SH2 domain containing protein 4A), also known as SH2A, is a ubiquitously expressed 454 amino acid docking protein that belongs to the SH2 signaling protein family. Members of this family typically participate in intracellular signaling. Localizing to the cytoplasm, SH2D4A contains one Src homology 2 (SH2) domain. SH2 domains bind to tyrosine-phosphorylated regions of target proteins, frequently linking activated growth factors to putative signal transduction proteins. This suggests that SH2D4A, via its SH2 domain, may play an important function in cellular signal transduction. More specifically, SH2D4A is believed to function as an inhibiting factor in PKC signal transduction. In addition, SH2D4A exhibits abnormal expression in various cancers, implying that it may be involved in tumorigenesis.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SH2D4A polyclonal antibody detects endogenous levels of SH2D4A protein.

Bioworld Molecular Weight: ~ 52 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of SH2D4A polyclonal antibody at 1:500 dilution
Lane 1: HEK293T whole cell lysate
Lane 2: Raw264.7 whole cell lysate
Lane 3: PC12 whole cell lysate

Immunogen: A synthetic peptide corresponding to residues in Human SH2D4A.

Conjugate: Unconjugated

Modification: Unmodified