CCR4 Polyclonal Antibody

Catalogue Numbers: BS60964-50, BS60964-100

Sizes: 50µl, 100µl

Alternative Name: C-C chemokine receptor type 4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4; K5-5; CD194; CCR4; CMKBR4

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P51679

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB

All Applications: WB: 1:500~1:1000

Background: C-C or β chemokine family members are characterized by a pair of adjacent
cysteine residues and serve as potentchemoattractants and activators of monocytes and T cells. C-C chemokine receptor family members include CKR-1,CKR-2A, CKR-2B, CKR-3, CKR-4, CKR-5, CKR-6, CKR-7 and the Duffy blood group antigen. Each of these receptors are G protein-coupled,seven pass
transmembrane domain proteins whose major physiological role is to function
in the chemotaxis of T cells and phagocytic cells to areas of inflammation.
However, this receptor family has also been shown to facilitate viral infection.
CKR-4 (C-C chemokine receptor type 4), also known as CCR4 or CMKBR4, is
a 360 amino acidmulti-pass membrane protein that localizes to the cell membrane and belongs to the C-C chemokine receptor family. Expressed at high levels in peripheral blood leukocytes and thymustissue, CKR-4 functions as a high affinity receptor for C-C type chemokines and is thought to be involved
in hippocampal-neuron survival.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CCR4 polyclonal antibody detects endogenous levels of CCR4 protein.

Bioworld Molecular Weight: ~ 41 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of CCR4 polyclonal antibody at 1:500 dilution
Lane 1: HEK293T whole cell lysate
Lane 2: NIH-3T3 whole cell lysate

Immunogen: A synthetic peptide corresponding to residues in Human CCR4.

Conjugate: Unconjugated

Modification: Unmodified