Pim-1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES6589-50, ES6589-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011],

Alternate Name: PIM1; Serine/threonine-protein kinase pim-1

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human Pim-1. AA range:281-330

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 50kD

Human Gene ID: 5292

Human SWISS Prot NO: P11309

Subcellular Location: [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Cell membrane.

Research Use Only