NPRL2 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-91550-60, E-AB-91550-120, E-AB-91550-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: NPRL2

Target Synonym: NPRL2; FFEVF2; NPR2; NPR2L; TUSC4; NPR2-like

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Rat

Application: WB

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q8WTW4

Background: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.

Concentration: 1mg/mL

Immunogen: Recombinant fusion protein of human NPRL2

Buffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000

Calculated MW: 23kDa/43kDa

Observed MW: 44kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only