tPA rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES6601-50, ES6601-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016],

Alternate Name: PLAT; Tissue-type plasminogen activator; t-PA; t-plasminogen activator; tPA; Alteplase; Reteplase

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human tPA. AA range:38-87

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 63kD

Human Gene ID: 5327

Human SWISS Prot NO: P00750

Subcellular Location: Secreted, extracellular space.

Research Use Only